The effects of
Cannabidiol inside the body
Cannabidiol does not stimulate the CB1 and CB2 receptors.
Instead, it activates other receptors, like the vanilloid, adenosine and serotonin receptors. By activating the TRPV-1 receptor, for example, cannabidiol plays a role in the regulation of body temperature, pain perception and inflammation . Then, cannabidiol inhibits the FAAH enzyme, a compound that activates the CB1 receptor. By doing so, cannabidiol minimizes the activation of CB1 by THC, reducing its psychoactive effects.
The activation of adenosine receptors by cannabidiol gives the anti-anxiety and anti-inflammatory effects of cannabidiol. Adenosine receptors are also involved in the release of dopamine and glutamate, two neurotransmitters that play major roles inside the body. Dopamine is involved in cognition, motor control, motivation and reward mechanisms, while glutamate is one of the major mediators of excitatory signals, being involved in memory, learning, and cognition.
High concentrations of cannabidiol have been shown to activate the 5-HT1A serotonin receptor, exerting anti-depressant effects. The same receptor is involved in a series of processes from pain perception, appetite, nausea and anxiety to sleep and addiction mechanisms. Finally, cannabidiol blocks CPR55 signaling, decreasing bone reabsorption and cancer cell proliferation. GPR55 is widely present inside the brain, being linked with the modulation of bone density and blood pressure, as well as with cancer cell proliferation.
As previously said, cannabidiol blocks the psychoactive action of THC, this being one of the reasons it’s generally considered advantageous to combine cannabidiol and THC when for treatment purposes. However, the positive effects of cannabidiol are not dependent on the presence of THC, so our Zero THC product still provides the cannabidiol health benefits.